Sex steroids and the construction and conservation of the adult skeleton.
By B. Riggs, S. Khosla, L. Melton. Endocrine reviews, 2002
1,864 citations recorded by the source corpus.
Subfields: Genetics, Orthopedics and Sports Medicine, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/d6728863eef94a8d3983f2cec9ae628627a2ab50
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In Orthopedics and Sports Medicine
Citations in the corpus
- TSH is a negative regulator of skeletal remodeling. (2003, background): “Normally, elevated osteoclastic resorption, for example, after go- This is consistent with our demonstration that (1) the in vitro effects of TSH are exerted separately on osteoblast nadal steroid withdrawal, precedes and exceeds the enhanced bone formation with the primary cellular de- and osteocla”
- FSH directly regulates bone mass. (2006, positive): “The elevated bone resorption in hypogonadism arises mainly from increased osteoclast formation, a phenomenon that has been attributed to estrogen deficiency (Riggs et al., 2002).”
- Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. (2010, background): “1 Non-placebo-controlled studies Lowering of testosterone concentrations in adult men by surgical orchiectomy or by GnRH agonist or antagonist administration is associated with rapid and marked loss of bone mineral density (29), increase in fat mass (45), and a TABLE 3.”
- Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. (2018, neutral): “…measuring T concentrations; these include men with low libido, erectile dysfunction, infertility, HIV-associated weight loss, osteoporosis or low-trauma fracture, a history of AAS use, and men receiving opioids or other drugs or substances that affect T production or metabolism (5, 6, 35 – 41).”
- SOST is a target gene for PTH in bone. (2005, background): “OVX-induced estrogen deprival enhances bone turnover by increasing bone resorption and at early stages also formation [42], with bone resorption exceeding formation resulting in net bone loss.”
- The decline of androgen levels in elderly men and its clinical and therapeutic implications. (2005, background): “bone mass and the preservation of adult skeletal integrity (62, 63).”
- Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. (2006, background): “Lowering of testosterone concentrations in adult men by surgical orchiectomy or by GnRH agonist or antagonist administration is associated with rapid and marked loss of bone mineral density (16), increase in fat mass (26), and a loss of muscle mass and strength (26).”
- Population‐Based Study of Age and Sex Differences in Bone Volumetric Density, Size, Geometry, and Structure at Different Skeletal Sites (2004, background): “The mechanism for the onset of decreases in cortical vBMD in the perimenopausal interval in women almost certainly is the increase in bone turnover induced by acute estrogen deficiency, which leads to increased cortical porosity.((41)) In the male cohort, there was also a decrease in cortical vBMD i”
- Growth hormone, insulin-like growth factors, and the skeleton. (2008, background): “Estrogen deficiency plays a role in the pathogenesis of postmenopausal osteoporosis and possibly male osteoporosis (375, 376).”
- Effects of obesity on bone metabolism (2011, background): “Bone mass and strength decrease during adulthood, especially in women after menopause [8].”