TLRs and innate immunity.

By B. Beutler. Blood, 2009

869 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a6babb12ca2a9f337e85714284fc833bfcd0a09a

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In Immunology

Citations in the corpus

Vaccine Adjuvants: Putting Innate Immunity to Work (2010, background): “…such as peptidoglycan species, flagellin, toxins, and ATP; helicases (RIG-I-like receptors, RLR) triggered by cytoplasmic RNA; and C-type lectin receptors (CLRs) recognizing carbohydrates and lipids (Beutler, 2009; Iwasaki and Medzhitov, 2010; Kawai and Akira, 2010; Takeuchi and Akira, 2010).”
Biological roles of glycans (2016, background): “It is now well recognized that innate immune cells also detect Pathogen-Associated Molecular Patterns (PAMPs) using Pattern Recognition Receptors (PRRs) (815, 816), particularly Toll-like receptors (TLRs) (817, 818), Nod-like receptors (NLRs) (819–822), and C-type lectins (823–826).”
Cellular and Molecular Players in Adipose Tissue Inflammation in the Development of Obesity-induced Insulin Resistance (2013, neutral): “The question is then, “How does obesity activate the IKKβ/NFκB pathway?” Since TLRs are considered to be major upstreammolecules in the activation of the IKKβ/NFκB pathway in many immune systems [111], the role of the TLR signaling pathway in the development of obesity-induced inflammation and insul”
NAFLD: a multisystem disease. (2015, background): “, an upstream activator of NF-jB signaling [35]) by gut microbiota-derived ligands, such as lipopolysaccharide may occur.”
Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. (2016, background): “pathogen-associated molecular patterns (PAMPs), including viruses, bacteria, fungi, and parasites (Beutler, 2009; Kawasaki and Kawai, 2014).”
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. (2011, background): “They are also the most well characterized and recognize a wide range of PAMPs (Akira et al., 2006; Beutler, 2009; Hoffmann, 2003;Medzhitov, 2007).”
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. (2013, background): “LPS signaling is initiated by activation of the MD2:toll-like receptor 4 (TLR4) on myeloid cells.(7,10) Eritoran (E5564), a synthetic analog of lipid A and a potent and specific antagonist of LPS action, inhibits lipid A binding to MD2 and terminates MD2/TLR4mediated signaling invitro, exvivo, and i”
Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids (2018, background): “Innate immune system receptors that are capable of recognizing PAMPs are called pattern recognition receptors, and these induce the expression of pro-inflammatory cytokines—for example, TNF-α and IL-1β—as well as activating the host’s antimicrobial defense mechanisms, such as the synthesis of reacti”
The Role of TLR2 in Infection and Immunity (2012, background): “To date, 13 TLRs have been identified, 10 human TLRs (TLR1-10), and 12 mouse TLRs (TLR1-9, TLR11, TLR12, mice do not express TLR10; Beutler, 2009).”