SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

By H. Unoki, A. Takahashi, T. Kawaguchi, K. Hara, M. Horikoshi, G. Andersen, D. Ng, J. Holmkvist, K. Borch-Johnsen, T. Jørgensen and 20 more. Nature Genetics, 2008

755 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a6acb2dd75fc523fe8b2c56b6f02c3d79d6a338d

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Citations in the corpus

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes (2012, neutral): “Both signals at KCNQ1 have previously been reported in East Asian and European populations 4,24 .”
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians (2011, background): “In addition, most of the T2D loci were detected initially in population samples of European origin, with the exceptions of KCNQ1 , UBE2E2 and C2CD4A-C2CD4B , which were first identified in studies of east Asian population”
Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention (2014, neutral): “8×10-13 [24]”
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico (2013, background): “85 in 1000 Genomes samples from the Americas) and co-segregate on a single haplotype; (2) common in samples of Latin American ancestry; and (3) show equivalent levels of association to type 2 diabetes (P 5 2.”
Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus (2010, background): “It is presumed that most cases involve multiple genetic factors, with some of these now elucidated [21, 22].”
Globalization of Diabetes (2011, background): “Conversely, a variant in the KCNQ1 gene associated with a 20–30% increased risk of diabetes in several Asian populations (43,44) is common in East Asians, but rare in Caucasians.”
Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups (2010, background): “With the exception of the KCNQ1 locus which was identified in the Japanese population [1,2], all of the well-replicated risk variants were first identified in populations of Northern European ancestry [3–13].”
Signals of recent positive selection in a worldwide sample of human populations. (2009, background): “MLPH is known to influence pigmentation in mouse (Matesic et al. 2001), dog (Drogemuller et al. 2007), cat (Ishida et al. 2006), and chicken (Vaez et al. 2008), and RGS19 was recently shown to influence pigmentation in mouse (McGowan et al. 2008).”
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (2010, background): “This signal maps ~150 kb from T2D-associated SNPs in the 3 ′ end of KCNQ1 first identified in East Asian GWA scans 8 , 9 .”