MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice

By A. Bonauer, G. Carmona, Masayoshi Iwasaki, M. Mione, M. Koyanagi, A. Fischer, Jana S. Burchfield, Henrik Fox, C. Doebele, Kisho Ohtani and 6 more. Science, 2009

1,283 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a630f71c369c47273cf9fb9f111f5912c33bad38

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Citations in the corpus

MicroRNAs in stress signaling and human disease (2012, background): “Systemic delivery of antisense oligonucleotides directed against miR-92a in a mouse model of hindlimb ischemia increases blood vessel growth and improves recovery from ischemic damage (Bonauer et al., 2009).”
Non‐coding RNAs: regulators of disease (2010, background): “For example, miR-92a controls functional recovery of ischaemic tissues in mice [157], and miR-145 and miR-143, which have recently been implicated in differentiation of progenitors into cardiac myocytes, are down-regulated in injured and atherosclerotic vessels [158].”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, positive): “, by injecting miRNA inhibitors in small and large animal models of myocardial infarction (MI) or kidney ischemia (24, 76, 108, 170).”
MicroRNAs in development and disease. (2011, background): “In contrast, overexpression of miR-92a in endothelial cells blocked tubulogenesis and was associated with reduced cell migration and adhesion, but did not affect viability or proliferation (52).”
Ischemia and reperfusion—from mechanism to translation (2011, background): “For example, a recent study showed that the miR-17∼92 cluster is highly expressed in human endothelial cells and that miR-92a, a component of this cluster, controls angiogenesi”
Molecular control of endothelial cell behaviour during blood vessel morphogenesis (2011, background): “Other vascular miRNAs seem to have critical roles during pathological angiogenesi”
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. (2009, background): “miRNAs act as negative regulators of gene expression by annealing with complementary sequences in the 39 untranslated regions (UTRs) of mRNAs, causing translational inhibition and mRNA degradation ( Bartel 2004 ).”
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease (2013, positive): “MiR-92a is highly expressed in endothelial cells but overexpression of miR-92a in those cells under ischemic conditions was shown to inhibit angiogenesis.(92) In a mouse model with leg ischemia, the administration of antagomiR-92a led to inhibition of miR-92a with consequent growth of new blood vess”
Therapeutic Strategies for Enhancing Angiogenesis in Wound Healing (2018, background): “Inhibition of miR-92a also improved wound healing and angiogenesis in a full thickness excisional wound model, specifically through decreasing activity of integrin subunit α5 (Itga5) and sirtuin-1 (Sirt1) [212,213].”