Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

By F. Weinberg, R. Hamanaka, W. Wheaton, S. Weinberg, J. Joseph, Marcos López, B. Kalyanaraman, G. Mutlu, G. Budinger, Navdeep S. Chandel. Proceedings of the National Academy of Sciences of the United States of America, 2010

1,667 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a5ed0250f289d5dd541d24ff547a753200b54574

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Navdeep S. Chandel
2. M. V. Vander Heiden
3. Ralph J. Deberardinis
4. C. V. Dang
5. Craig B. Thompson
6. Alec C. Kimmelman
7. Erika L. Pearce
8. E. White

In Molecular Biology

1. Navdeep S. Chandel
2. Ralph J. Deberardinis
3. M. V. Vander Heiden
4. C. V. Dang
5. Guido Kroemer
6. Craig B. Thompson
7. L. Galluzzi
8. Alec C. Kimmelman

Citations in the corpus

• Oxidative Phosphorylation as an Emerging Target in Cancer Therapy (2018, background): “demonstrated that mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity (13).”
• Mitochondrial reactive oxygen species and cancer (2014, background): “In addition, loss of mitochondrial transcription factor A (TFAM), a transcription factor required for mtDNA replication, inhibited tumor formation in an in vivo mouse model of K-Ras-driven lung cancer [69].”
• Glutaminolysis: A Hallmark of Cancer Metabolism. (2017, background): “Accordingly, glutamine can enhance the oxygen consumption rate and ATP production in KRASmutant cells to promote tumorigenesis (85).”
• Understanding the intersections between metabolism and cancer biology (2017, neutral): “Cancer cells require oxidative metabolism to form tumors (Davidson et al., 2016b; Weinberg et al., 2010).”
• Nrf2, the Master Regulator of Anti-Oxidative Responses (2017, background): “On the other hand, ROS are also involved in tumor growth and progression [97,98].”
• Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis (2014, positive): “Our current findings bolster our previous findings highlighting the importance of mitochondrial metabolism as essential for cancer proliferation (Weinberg et al., 2010; Sullivan et al., 2013).”
• Mitochondrial metabolism and cancer (2017, background): “The term “malignant transformation” generally refers to the conversion of a normal cell into a neoplastic precursor that – in the context of failing immunosurveillance – acquires additional alterations enabling unrestricted proliferative potential, dissemination and formation of distant macrometasta”