Koch's postulates fulfilled for SARS virus

By R. Fouchier, T. Kuiken, M. Schutten, G. van Amerongen, G. V. van Doornum, B. G. van den Hoogen, M. Peiris, W. Lim, K. Stöhr, A. Osterhaus. Nature, 2003

843 citations recorded by the source corpus.

Severe acute respiratory syndrome (SARS) has recently emerged as a new human disease, resulting globally in 435 deaths from 6,234 probable cases (as of 3 May 2003). Here we provide proof from experimental infection of cynomolgus macaques (Macaca fascicularis) that the newly discovered SARS-associated coronavirus (SCV) is the aetiological agent of this disease. Our understanding of the aetiology of SARS will expedite the development of diagnostic tests, antiviral therapies and vaccines, and may allow a more concise case definition for this emerging disease.

Subfields: Epidemiology, Infectious Diseases, Modeling and Simulation

View Paper: https://www.semanticscholar.org/paper/663a60d6e380cd6e5ea4819ea9df3b4ec3664d1f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

In Infectious Diseases

In Modeling and Simulation

Citations in the corpus

An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus (2004, neutral): “The outbreak of SARS in March 2003 caused by SARS-CoV represents the most recent threat to human health [14] [15] [16] [17] .”
Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection (2007, background): “Orf9b (98) Crystal structure of Orf9b, an alternative ORF within the N gene, may be involved in membrane attachment and associates with intracellular vesicles, consistent with a role in assembly of the virion (241) VOL.”
Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 (2005, background): “SARS coronavirus (SARS-CoV) is the etiological agent of severe acute respiratory syndrome (SARS), an acute pulmonary syndrome that, when it emerged in the winter of 2002-2003, resulted in the death of approximately 800 individuals, close to 10% of those infected Fouchier et al, 2003; Ksiazek et al, ”
Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus (2005, background): “Proof that this virus is the etiologic agent for SARS was provided by results of infections carried out in nonhuman primates, in which Koch’s postulates were fulfilled (102).”
Mechanisms and enzymes involved in SARS coronavirus genome expression. (2003, background): “There is now clear evidence that SARS is caused by a previously unknown coronavirus, provisionally termed SARS coronavirus (SARS-CoV) (Peiris et al., 2003b; Drosten et al., 2003; Ksiazek et al., 2003; Fouchier et al., 2003).”
SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat (2020, background): “CoVs have been identified in both avian hosts and various mammals, including bat, camels, dogs and masked palm civets, and are previously regarded as pathogens that only cause mild diseases in the immunocompetent people until the emergence of the coronavirus causing severe acute respiratory syndrome”
Coronavirus Pathogenesis (2011, background): “fascicularis) (Fouchier et al., 2003; Kuiken et al., 2003; Rowe et al., 2004), rhesus macaques (Macaca mulatta) (McAuliffe et al.”
Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection (2003, background): “7 The coronaviruses are a diverse group of large, enveloped, positive-stranded RNA viruses.”
Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings (2004, methodology): “Initial screening was performed in 96-well microtitre plates seeded with fetal rhesus kidney-4.”