Mechanisms and enzymes involved in SARS coronavirus genome expression.

By V. Thiel, Konstantin A. Ivanov, A. Putics, Tobias Hertzig, B. Schelle, S. Bayer, B. Weissbrich, E. Snijder, H. Rabenau, H. Doerr and 2 more. Journal of General Virology, 2003

832 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/d71047926fe46b275326b25a59bb8b30cec470fc

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Citations in the corpus

Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome (2020, neutral): “The frameshifting occurs with high efficiency (25-75% depending on the system used ( 5 – 9 ) and changes the reading frame to UUU_AAA_C ( 10 ) (Fig.”
The Molecular Biology of Coronaviruses (2006, background): “Knowledge gained from these efforts allowed the informed prediction (Snijder et al., 2003; Thiel et al., 2003a) and rapid experimental verification (Harcourt et al., 2004; Prentice et al., 2004b) of the processing pathway for the SARS-CoV replicase.”
SARS-CoV-2 invades host cells via a novel route: CD147-spike protein (2020, background): “These viruses are known to have four structural proteins, including E, M, N and S protein [3,4].”
Petabase-scale sequence alignment catalyses viral discovery (2020, background): “Accurate annotation of CoV genomes is challenging owing to ribosomal frameshifts and polyproteins that are cleaved into maturation proteins 68 , and thus previously annotated viral genomes offer a guide to accurate gene-calls and protein functional predictions.”
SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum (2008, methodology): “Doerr [JohannWolfgang-Goethe-Universität, Frankfurt am Main, Germany]; [15]) was used to infect Vero E6 cells.”
The Role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus Pathogenesis (2012, background): “The SARS-CoV ORF7a protein, also known as ORF8 [21], U122 [96] or X4 [22,97], is encoded by the first ORF of sgRNA7 [25,26].”
Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus (2005, background): “deletion of 45 nucleotides was found to occur in ORF 7b after three passages of SARS-CoV in tissue culture (311).”
Competing Interests: The authors (2006, neutral): “T:C:G:A variant is also present in the Frankfurt-1 isolate [15], which was contracted from the early Singaporean patient”
The Coronavirus Nucleocapsid Is a Multifunctional Protein (2014, background): “The last third of the genome produces subgenomic (sg) mRNAs that encode the four structural proteins, spike (S), envelope (E), membrane (M), and nucleocapsid (N), as well as a number of accessory proteins [10, 11] .”
Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage (2003, methodology): “The newly described putative enzymes of SARS-CoV double the list of potential targets for the design of antiviral strategies aimed at controlling this emerging virus infection.(33,34)”
Computational studies of drug repurposing and synergism of lopinavir, oseltamivir and ritonavir binding with SARS-CoV-2 protease against COVID-19 (2020, background): “CoVs encode proteases such as papain-like protease (PLpro) and main protease (Mpro) (Thiel et al., 2003), which are involved in the proteolytic processing of the polyproteins into individual non-structural proteins (nsps) to control viral gene expression and replication (Xue et al., 2008).”