The Major Green Tea Polyphenol, (−)-Epigallocatechin-3-Gallate, Inhibits Obesity, Metabolic Syndrome, and Fatty Liver Disease in High-Fat–Fed Mice,

By Mousumi Bose, J. Lambert, Jihyeung Ju, K. Reuhl, S. Shapses, Chung S. Yang. Journal of NutriLife, 2008

619 citations recorded by the source corpus.

In this study, we investigated the effects of the major green tea polyphenol, (−)-epigallocatechin-3-gallate (EGCG), on high-fat–induced obesity, symptoms of the metabolic syndrome, and fatty liver in mice. In mice fed a high-fat diet (60% energy as fat), supplementation with dietary EGCG treatment (3.2 g/kg diet) for 16 wk reduced body weight (BW) gain, percent body fat, and visceral fat weight (P < 0.05) compared with mice without EGCG treatment. The BW decrease was associated with increased fecal lipids in the high-fat–fed groups (r2 = 0.521; P < 0.05). EGCG treatment attenuated insulin resistance, plasma cholesterol, and monocyte chemoattractant protein concentrations in high-fat–fed mice (P < 0.05). EGCG treatment also decreased liver weight, liver triglycerides, and plasma alanine aminotransferase concentrations in high-fat–fed mice (P < 0.05). Histological analyses of liver samples revealed decreased lipid accumulation in hepatocytes in mice treated with EGCG compared with high-fat diet-fed mice without EGCG treatment. In another experiment, 3-mo-old high-fat–induced obese mice receiving short-term EGCG treatment (3.2 g/kg diet, 4 wk) had decreased mesenteric fat weight and blood glucose compared with high-fat–fed control mice (P < 0.05). Our results indicate that long-term EGCG treatment attenuated the development of obesity, symptoms associated with the metabolic syndrome, and fatty liver. Short-term EGCG treatment appeared to reverse preexisting high-fat–induced metabolic pathologies in obese mice. These effects may be mediated by decreased lipid absorption, decreased inflammation, and other mechanisms.

Subfields: Biological Psychiatry, Epidemiology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/a59044980ea48bb561b82917c015855fb3bd9415

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Citations in the corpus

Impact of Dietary Polyphenols on Carbohydrate Metabolism (2010, background): “In mice fed high-fat diet indications towards beneficial effect in glucose/insulin signaling have been obtained by catechin [172], EGCG [134], grape seed procyanidins [173], and blueberry [174].”
Novel insights of dietary polyphenols and obesity. (2014, background): “Preclinical studies in animals [32–54] further confirmed the beneficial effects of EGCG or GTE on obesity-related parameters including decreased BW [34, 35, 37, 39, 42–45, 47–54], adipose mass [32–35, 37, 39–42, 44, 45, 47, 50–54], total lipids, cholesterol, triglyceride (TG), and triacylglycerol (T”