Regulation of matrix biology by matrix metalloproteinases.

By J. Mott, Zena Werb. Current Opinion in Cell Biology, 2004

1,155 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/a57ff85b949cfa7c4b66c8676ce4e14e973b282d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Pengfei Lu
2. Valerie M. Weaver
3. Zena Werb
4. W. Parks
5. Andrew J. Ewald
6. M. Egeblad
7. T. Cox
8. R. Khalil

In Molecular Biology

1. Pengfei Lu
2. Valerie M. Weaver
3. Zena Werb
4. M. Egeblad
5. T. Cox
6. W. Parks
7. Andrew J. Ewald
8. J. Erler

In Oncology

1. Pengfei Lu
2. Zena Werb
3. Valerie M. Weaver
4. M. Egeblad
5. W. Parks
6. Andrew J. Ewald
7. T. Cox
8. J. Erler

Citations in the corpus

• Extracellular Matrix Degradation and Remodeling in Development and Disease (2011, background): “5) (Mott and Werb 2004).”
• Kisspeptins and reproduction: physiological roles and regulatory mechanisms. (2012, background): “For example, matrix metalloproteases (MMPs) have been implicated in tumor metastasis (506, 512) and trophoblast invasion (71), likely due to their ability to affect cellular interactions with the extracellular matrix, and hence cell division, migration, and morphogenesis (290).”
• The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective (2019, background): “Recently it has been shown that STRAP governs the inhibitory functions of SMAD7 (Liu, Li, Peng, Liu, & Liu, 2007) (Liu et al., 2006; Anastasiadis & Reynolds, 2001; Mott & Werb, 2004; Figure 5).”
• Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. (2018, background): “MMP-2, MMP-9, MMP-13 and MMP-14 release growth factors such as TGF-h and VEGF that are stored in ECM (Mott and Werb, 2004).”
• Role of Matrix Metalloproteinases in Angiogenesis and Cancer (2019, background): “Specifically, MMP-2 and MMP-9 give rise to the modulation of the dynamic remodeling of ECM (editing aggrecan, collagens, elastin, fibronectin, laminins, and glycosaminoglycans, and latent signaling proteins), activating and deactivating by proteolytic cleavages releasing biological activities that i”
• Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer (2011, background): “…proteases (Roycik et al., 2009), and the large superfamily of metzincins, which includes ADAMs (a disintegrin and metalloproteinases), ADAMTSs (ADAMs with thrombospondin motifs), and matrix metalloproteases (MMPs) and their inhibitors [tissue inhibitor of MMPs (TIMPs)] (Mott and Werb, 2004).”
• The extracellular matrix at a glance (2010, background): “Tissue homeostasis is mediated by the coordinated secretion of fibroblast metalloproteinases (MMPs) (Mott and Werb, 2004); this is counterbalanced by tissue inhibitors of metalloproteinases (TIMPs) (Cruz-Munoz and Khokha, 2008) and the controlled activity of other enzymes, such as LOX, and also…”
• Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, background): “In order to do this, we examined imaginal discs where the BM had been degraded by targeted expression of matrix metalloproteases (MMPs); these enzymes are capable of degrading most extracellular matrix components (Mott and Werb, 2004).”
• What is Intervertebral Disc Degeneration, and What Causes It? (2006, background): “Disc cells synthesize their matrix and break down existing matrix by producing and activating degradative enzymes, including matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase (ADAMS).[14-20] Molecular markers of matrix turnover are naturally most plentiful during growth but us”
• Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. (2011, background): “MMPs can also cleave other proteins such as growth factors and cell adhesion molecules, in some cases releasing active molecules (Mott & Werb 2004).”
• Metalloproteinases and their inhibitors: regulators of wound healing. (2008, background): “…IH -PA Author M anuscript N IH -PA Author M anuscript membrane or ECM, cleavage of growth factor receptors from the cell surface, shedding of cell adhesion molecules, and activation of other MMPs, among other, non-catabolic functions (Egeblad & Werb, 2002; Mott & Werb, 2004; Parks et al., 2004).”
• Overview of the matrisome--an inventory of extracellular matrix constituents and functions. (2012, background): “These various proteolytic processes play roles in ECM turnover and are thought to release ECM-bound growth factors and also to expose cryptic activities in the ECM (Mott and Werb 2004; Ricard-Blum 2011), including the release of antiangiogenic inhibitors (Bix and Iozzo 2005; Nyberg et al.”