TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.

By A. Kanayama, Rashu B. Seth, Lijun Sun, Chee-Kwee Ea, Mei Hong, Abdullah Shaito, Y. Chiu, L. Deng, Zhijian J. Chen. Molecules and Cells, 2004

956 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a565ee3d298615ab982829ab01cde46f811893be

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In Cancer Research

1. Shizuo Akira
2. Taro Kawai
3. K. Takeda
4. O. Takeuchi
5. Ivan Dikic
6. Shintaro Sato
7. D. Komander
8. Masahiro Yamamoto

In Immunology

1. Shizuo Akira
2. Taro Kawai
3. O. Takeuchi
4. K. Takeda
5. R. Medzhitov
6. Zhijian J. Chen
7. R. Randall
8. S. Goodbourn

In Molecular Biology

1. Shizuo Akira
2. D. Komander
3. Taro Kawai
4. Ivan Dikic
5. Zhijian J. Chen
6. O. Takeuchi
7. G. Núñez
8. N. Inohara

Citations in the corpus

• Ubiquitin and ubiquitin-like proteins as multifunctional signals (2005, background): “This triggers the TAK1 complex to bind to the membrane-receptor complex through the K63-linked polyubiquitin chains, and results in IκB phosphorylation and its subsequent ubiquitylatio”
• Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. (2012, background): “This complex is required for efficient activation by IL-1 and PAMPs of NF- B and, at least in some circumstances, JNK and p38 (140, 222, 304, 332) (FIGURE 6B).”
• Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “TRAF6 recruitment can activate NF-kB through TAK1–TAB2–TAB3 and the canonical IKK complex, and this route is followed for NF-kB activation in response to TLR7 engagement.”
• Essential function for the kinase TAK1 in innate and adaptive immune responses (2005, background): “It is possible TAB3, a homolog of TAB2, functions redundantly in TAB2-deficient mic”
• Ubiquitylation in innate and adaptive immunity (2009, background): “TAB2 and TAB3 bind preferentially to Lys 63 polyubiquitin chain”
• The NF-κB pathway (2005, background): “B-Ras also increases the stability of I B (Kanayama et al., 2004).”
• A ubiquitin ligase complex assembles linear polyubiquitin chains (2006, background): “The 600K complex assembles polyubiquitin chains NZF has been reported to function as a ubiquitin-binding motif (Meyer et al, 2002; Kanayama et al, 2004; Hicke et al, 2005).”
• NF-κB activation as a pathological mechanism of septic shock and inflammation (2006, neutral): “Interaction between these polyubiquitin chains on TRAF6 and the zinc finger domain of TAB1, TAB2, or TAB3 leads to the formation TRAF-6-TAB1/2/3-TAK1 complex (117).”
• Ubiquitin signalling in the NF-κB pathway (2005, background): “TAB2 and its related protein TAB3 contain a highly conserved novel zinc-finger (NZF) domain that binds preferentially to polyubiquitin chains that are linked by Lys 63 (ref”
• Molecular Basis of NF-κB Signaling (2013, background): “(c) Crystal structure of TAB2 NZF in complex with Lys63-linked di-ubiquitin.”