Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus.

By I. Baumann, W. Kolowos, R. Voll, B. Manger, U. Gaipl, W. Neuhuber, T. Kirchner, J. Kalden, M. Herrmann. Arthritis & Rheumatism, 2002

597 citations recorded by the source corpus.

Subfields: Immunology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/a5517682dc5cf82ee2e011b79302ad595f4313d4

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In Immunology

1. Guido Kroemer
2. L. Zitvogel
3. L. Galluzzi
4. M. Smyth
5. Oliver Kepp
6. S. Formenti
7. S. Demaria
8. A. Buqué

Citations in the corpus

• Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview (2017, background): “These self-antigens are presented to autoreactive B cells in germinal centers in secondary lymphoid organs by follicular dendritic cells, thus generating autoantibodies against cellular components derived from NETosis and apoptosis (134, 135).”
• The role of defective clearance of apoptotic cells in systemic autoimmunity (2010, result): “However, in some patients with SLE, the number of tingible body macrophages that contained ingested apoptotic material was considerably reduced; these cells lacked the typical morphology and were smaller compared with those of non-SLE patients”
• Consensus guidelines for the detection of immunogenic cell death (2014, background): “Of note, defects in the clearance of apoptotic cells by professional phagocytes have been associated with autoimmune conditions such as systemic lupus erythematosus and chronic inflammation.(26,27) However, it remains unclear whether this reflects the immunogenic potential of intact apoptotic corpse”
• Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer (2016, background): “cells that have acquired auto-reactivity during the process of somatic mutation.(38) IgG auto-antibodies recognizing second-”
• Immunobiology of the TAM receptors (2008, background): “, and elevated numbers of apoptotic cells are often seen in the germinal centres of lymph nodes and other lymphoid organs in human autoimmune syndrome”