X-chromosome inactivation: counting, choice and initiation

By P. Avner, Edith Heard. Nature reviews genetics, 2001

662 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a4e7cd2c59d72d1900b8994bf22f61316a4fef87

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In Genetics

1. C. D. Allis
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4. Janet Rossant

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Citations in the corpus

• An epigenetic road map for histone lysine methylation (2003, background): “X-inactivation – choosing an exit with H3-K9 and H3-K27 Dosage compensation in female mammals involves chromosome-wide inactivation of one X-chromosome (Avner and Heard, 2001).”
• Fast and reliable prediction of noncoding RNAs (2005, neutral): “Non-coding RNAs (ncRNAs) are involved in a large variety of processes, including gene regulation [4], maturation of mRNAs, rRNAs, and tRNAs, or X-chromosome inactivation in mammals [5].”
• The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. (2004, background): “X-chromosome inactivation (X-inactivation) is a developmentally regulated process involving choice of the active X chromosome, initiation of silencing on the Xi and maintenance of silencing throughout all subsequent cell divisions [40,41].”
• A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains (2007, background): “After transcription, Xist spreads across the entire length of one of the two X-chromosomes in female cells, resulting in the transcriptional silencing of most other loci located on the inactive X [4,5].”
• FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst (2010, background): “The idea behind this model is that the PE and the trophectoderm (TE), the outer cell layer of the blastocyst, are both extraembryonic lineages and share similar epigenetic characteristics; for example, paternal X inactivation (reviewed by Avner and Heard, 2001).”
• Histone and chromatin cross-talk. (2003, background): “In female mammals, a single X chromosome is silenced during early embryogenesis in a stable and heritable fashion (for a review, see [93]).”