Disease-associated astrocytes in Alzheimer’s disease and aging
By Naomi Habib, C. McCabe, S. Medina, Miri Varshavsky-Hassid, D. Kitsberg, Raz Dvir-Szternfeld, G. Green, Danielle Dionne, Lan Nguyen, Jamie L. Marshall and 5 more. Nature Neuroscience, 2020
825 citations recorded by the source corpus.
The role of non-neuronal cells in Alzheimer’s disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer’s disease mouse model. These disease-associated astrocytes appeared at early disease stages and increased in abundance with disease progression. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors. A new subset of disease-associated astrocytes (DAAs) is identified in a mouse model of Alzheimer’s disease by single-nucleus RNA sequencing. DAAs are also found in aged wild-type mice, suggesting a link to genetic and age-related factors.
Subfields: Biological Psychiatry, Neurology, Physiology
View Paper: https://www.semanticscholar.org/paper/a4addb35b2fe4d7b1309b3d45e5f11aa59ce514f
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Citations in the corpus
- Astrocyte reactivity: Subtypes, states and functions in CNS innate immunity (2020, background): “For example, in some single-cell molecular analyses, astrocyte clusters most prevalent in baseline healthy tissue are referred to as ‘homeostatic’, and astrocytes in diseased tissue that are most different from ‘homeostatic’ astrocytes, are referred to as ‘disease-associated’ [63].”
- Astrocyte crosstalk in CNS inflammation (2020, background): “Indeed, astrocytes respond to inflammatory signals and can themselves promote inflammation, which makes them important players in neurologic diseases like multiple sclerosis (MS), Alzheimer disease (AD), Parkinson disease (PD), Huntington disease (HD) and amyotrophic lateral sclerosis (ALS) (Di Gior”