Astrocyte reactivity: Subtypes, states and functions in CNS innate immunity

By M. Sofroniew. Trends in immunology, 2020

603 citations recorded by the source corpus.

Astrocytes are neural parenchymal cells that ubiquitously tile the central nervous system (CNS). In addition to playing essential roles in healthy tissue, astrocytes exhibit an evolutionarily ancient response to all CNS insults referred to as astrocyte reactivity. Long regarded as passive and homogenous, astrocyte reactivity is being revealed as a heterogeneous and functionally powerful component of mammalian CNS innate immunity. Nevertheless, concepts about what astrocyte reactivity comprises and what it does are incomplete and sometimes controversial. Here, we discuss the goal of differentiating reactive astrocyte subtypes and states based on composite pictures of molecular expression, cell morphology, cellular interactions, proliferative state, normal functions and disease-induced dysfunctions. We present a working model and conceptual framework for characterizing astrocyte reactivity in its diversity.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/59d94dee768aa45eb07ad04c9c68d313bdcc6141

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In Neurology

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3. Yilong Ren
4. Rongrong Zhu
5. Xiao Hu
6. Jingwei Zhao
7. Zhaojie Wang
8. Bei Ma

Citations in the corpus

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