PL‐03‐01: INGE GRUNDKE‐IQBAL AWARD FOR ALZHEIMER'S RESEARCH: NEUROTOXIC REACTIVE ASTROCYTES ARE INDUCED BY ACTIVATED MICROGLIA

By S. A. Liddelow, Kevin A. Guttenplan, L. Clarke, F. C. Bennett, Christopher J. Bohlen, Lucas Schirmer, Mariko L. Bennett, Alexandra E. Münch, Won-Suk Chung, T. Peterson and 11 more. Alzheimer's & Dementia, 2019

3,621 citations recorded by the source corpus.

Subfields: Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/a46ab4b77fae8fffdb5536ecea1a09622b155767

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Citations in the corpus

Spinal cord injury: molecular mechanisms and therapeutic interventions (2023, background): “Transcriptome analysis can divide reactive astrocytes into different clusters or subtypes according to their molecular signatures.(33,135,149,150) For example, high-profile subtypes of A1 neurotoxic astrocytes and A2 neuroprotective astrocytes,(135,149) which may represent new therapeutic potential.”
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions (2022, background): “found that ERK negatively controlled autophagy by activating mTOR, which contributed to neuronal survival after experimental ischemic stroke injuries.(164) Furthermore, an in vitro OGD/R study revealed that ERK could modulate autophagy by regulating mTOR in oxygen-glucose deprivation models.”
The neuropathological diagnosis of Alzheimer’s disease (2019, background): “It is thought they react to the cytokines and other agents produced by pro-inflammatory M1 microglia, and these changes in the astrocytes are thought to be neurotoxic [88, 89].”
Astrocyte reactivity: Subtypes, states and functions in CNS innate immunity (2020, background): “For example, early transcriptome profiling studies identified an ‘A1’ molecular signature of 12 genes associated with a neurotoxic astrocyte subtype that emerged after exposure to specific cytokines secreted by microglia exposed to lipopolysaccharide (LPS), and an ‘A2’ molecular signature of 12 gene”
Overview of General and Discriminating Markers of Differential Microglia Phenotypes (2020, background): “The most widely used markers are ionized calcium-binding adapter molecule 1 (IBA1; Yun et al., 2018), cluster of differentiation receptors (CD68, CD11b, CD14, CD45, CD80, and CD115; Zanoni et al., 2011; Fadini et al., 2013; Jenkins et al., 2013; Jeong et al., 2013; Rice et al., 2017), fractalkine re”