IL-6 switches the differentiation of monocytes from dendritic cells to macrophages

By P. Chomarat, Jacques Banchereau, J. Davoust, A. Palucka. Nature Immunology, 2000

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How researchers see this paper

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Directing Transition from Innate to Acquired Immunity: Defining a Role for IL-61 (2005, background): “Channeling of this IL-6-directed differentiation might relate to the ability of IL-6 to induce expression of M-CSF receptors on monocytes (52).”
IL-6 signal transduction and its physiological roles: the signal orchestration model. (2003, neutral): “cytes (Chomarat et al. 2000; Mitani et al. 2000).”
Interleukin‐6 biology is coordinated by membrane‐bound and soluble receptors: role in inflammation and cancer (2006, background): “Specifically, IL-6 directs human monocytes away from a dendritic lineage to a macrophage phenotype [86, 87].”
The Two Faces of IL-6 in the Tumor Microenvironment (2014, background): “Significantly, the differentiation of Th17 cells and Treg are interconnected; naïve CD4+ T cells stimulated in the presence of TGF-β express Foxp3 and become functional Treg.”
Immune function of astrocytes (2001, background): “As well, a recent study has demonstrated that IL-6 controls monocyte differentiation into macrophages (Chomarat et al., 2000).”