Immune function of astrocytes

By Yuanshu Dong, E. Benveniste. Glia, 2001

1,307 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/2eab9ab5694a8cf49dacd9c35431574d7085a2a6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Hanani
2. M. F. Gulen
3. M. Sofroniew

In Neurology

1. M. Sofroniew
2. H. Vinters
3. M. Hanani
4. R. Swanson
5. Yongmei Chen
6. J. Burda
7. M. Pekny
8. G. Moalem-Taylor

Citations in the corpus

• Satellite glial cells in sensory ganglia: from form to function. (2005, background): “Cytokines have a variety of functions; for example interkeukin (IL-1h) is proinflammatory, whereas (IL-6) may be anti-inflammatory under certain circumstances and also has trophic and protective actions [14,42].”
• Astrocytes and Brain Injury (2003, background): “For example, IL6 and TNF- have been shown to promote demyelination, thrombosis, leukocyte infiltration, and blood–brain barrier disruption (Feuerstein et al., 1998; Dong and Benveniste, 2001).”
• The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease (2007, background): “Because astrocytes are responsive to IL-17 and are important in the production of cytokines and chemokines during EA”
• Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy (2003, background): “Both microglia and astroglia have the ability to release proinflammatory cytokines in response to nerve injury and inflammation (Aloisi, 2001; Dong and Benveniste, 2001).”
• The inflammatory response in stroke. (2007, background): “Astrocytes also participate in brain inflammation by expressing major histocompatibility complex (MHC) and costimulatory molecules, developing Th2 (anti-inflammatory) immune responses and suppressing interleukin-12 (IL-12) expression, though this has yet to be demonstrated in ischemia models (review”
• Astrocytes: biology and pathology (2009, background): “Astrocytes can produce a wide variety of pro- or anti-inflammatory molecules [58, 226], and can exert potent suppressive effects on inflammatory cells [114].”
• Insulin Action in Brain Regulates Systemic Metabolism and Brain Function (2014, background): “Moreover, astrocytes play key roles in regulating the homeostasis of the synaptic junction microenvironment, as well as inflammation (63,64).”