Adipose tissue, inflammation, and cardiovascular disease.

By A. Berg, P. Scherer. Circulation Research, 2005

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How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Mechanisms linking obesity with cardiovascular disease (2006, background): “Obesity is associated with both increased local adipose and more general inflammatio”
Uric Acid: The Oxidant-Antioxidant Paradox (2008, background): “important factor in shifting the balance of adipose-specific hormones and cytokines (adipokines) from the normal phenotype facilitating insulin sensitivity and maintaining vascular homeostasis towards a phenotype characterized by low-grade inflammation, insulin resistance, and dyslipidemia.[17,59] T”
Adipocytokines in Obesity and Metabolic Disease (2014, positive): “Numerous studies in humans have demonstrated strong associations between circulating TNFa and insulin resistance (Hivert et al. 2008) or other obesity-associated metabolic complications (Berg & Scherer 2005).”
The Critical Role of Metabolic Pathways in Aging (2012, background): “As opposed to other fat-derived cytokines that oppose insulin action, adiponectin is an insulin sensitizer with anti-inflammatory properties and a potent activator of AMP-activated protein kinase (AMPK) (10).”