BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

By B. J. Peter, H. Kent, I. Mills, Y. Vallis, P. Butler, P. Evans, H. McMahon. Science, 2004

1,728 citations recorded by the source corpus.

Subfields: Cell Biology

View Paper: https://www.semanticscholar.org/paper/a44098d4b1c58ca471027d05271b8abf2484d251

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In Cell Biology

1. Emmanuel Boucrot
2. T. Balla
3. Richard L. Huganir
4. Aurélien Roux
5. J. Gallop
6. H. McMahon
7. D. Suen
8. M. Lemmon

Citations in the corpus

• Identification of Targetable FGFR Gene Fusions in Diverse Cancers (2013, neutral): “As most of the diverse FGFR fusion partners contribute domains with known dimerization motifs, including coiled-coil, SAM, LIS1, BAR, SPHF, and caspase (23-29), we hypothesized that oligomerization may serve as the common mechanism of activation of FGFR fusion proteins.”
• Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins. (2005, background): “Activity In Vitro BAR domain proteins induce massive tubulation of liposomes in vitro (Farsad et al., 2001; Peter et al., 2004; Takei et al., 1999).”
• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “They have positive residues on the concave (BAR and F-BAR) or convex (I-BAR) surface that interact with acidic phospholipids in curved membranes (1211) and also have membrane-bending and curvature-generating activities (465).”
• Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy (2005, background): “, consistent with evidence that BAR domains can act as sensors of membrane curvatur”
• Membrane curvature and mechanisms of dynamic cell membrane remodelling (2005, background): “Also, many BAR-domain proteins have links by way of signalling proteins to the actin- and microtubule-polymerization machinery (for example tuba, β-centaurins and nadrin”
• Filopodia: molecular architecture and cellular functions (2008, background): “Intriguingly, the 3D structure of the IM/I-BAR domain shows remarkable similarity to BAR and F-BAR domains, which are membrane-deforming domains that induce plasma-membrane tubulation, for example, during endocytosi”
• A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis (2011, background): “The PI(4,5)P2 phosphatase synaptojanin2b1, which binds to the NBAR domain protein amphiphysin1 [49], had recruitment kinetics similar to those of dynamin and peaked at scission but showed little recruitment at time points before 220 s (Figure 4A).”
• Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor (2004, background): “The association of retromer with tubules is consistent with the presence in Snx1 and Snx2 of a BAR-like domain that has the ability to sense highly curved membranes (Peter et al., 2004).”
• Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling (2005, background): “uk/interpro/DisplayIproEntry?ac=IPR004148">BAR ('Bin, amphiphysin, Rvs') domains, which induce membrane curvature and help in the fission of clathrin-coated buds from the membran”