Metabolism and kinetics of bisphenol a in humans at low doses following oral administration.

By W. Völkel, Thomas Colnot, G. Csanády, J. Filser, W. Dekant. Chemical Research in Toxicology, 2002

983 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis

View Paper: https://www.semanticscholar.org/paper/a3fd269c06775495c00496e87a74647dc79da716

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Citations in the corpus

• Global Assessment of Bisphenol A in the Environment (2015, background): “When assessing BPA bioaccumulation, the scientific and regulatory communities have frequently relied on a study conducted by Volkel et al. (2002) and Colnot et al. (2002), which concluded that BPA was rapidly eliminated (t1/2 5.3 hours), primarily through glucuronidation.”
• Bisphenol A and human health: a review of the literature. (2013, background): “Total BPA contains both the 11 unconjugated and the biologically inactive conjugated fractions [194].”
• Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A (2010, critical): “In drawing their conclusion that there is no risk from current human exposure levels, Volkel et al. (2002) overlooked several important points from a risk assessment perspective.”
• A review of dietary and non-dietary exposure to bisphenol-A. (2012, background): “030 lg/kg bw/day Völkel et al. (2008)”
• Human exposure to bisphenol A (BPA). (2007, background): “[102] 2002 human 5 mg per person oral LC-MS/MS 1.”
• Urinary Concentrations of Bisphenol A and 4-Nonylphenol in a Human Reference Population (2004, methodology): “Orally administered BPA is rapidly metabolized to its monoglucuronide in rats (Pottenger et al. 2000) and humans (Volkel et al. 2002) and excreted in the urine.”
• Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. (2008, background): “From the few pharmacokinetic studies of human BPA metabolism, near-complete urinary excretion has been shown to occur within 24 hours of a single high dose.(37) Mahalingaiah et al(38) examined temporal variability in urinary concentrations and foundthatalthoughasecondsample could improve the sensiti”
• Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH) (2008, background): “…and are recognized as important contributions in the extrapolation process in the risk assessment (Amberg et al. 2001; Bernauer et al. 1996; Ernstgard et al. 2005; Fennell et al. 2005; Filser et al. 1992; Gunnare et al. 2006; IPCS 2006; Pähler et al. 1999; Schauer et al. 2006; Völkel et al. 2002).”
• Exposure of the U.S. Population to Bisphenol A and 4-tertiary-Octylphenol: 2003–2004 (2007, background): “In humans, orally administered BPA is conjugated to the monoglucuronide and excreted (Volkel et al. 2002), with an Human exposure to bisphenol A and 4-tertiary-octylphenol”
• EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. (2015, background): “Due to its ubiquitous nature and continuous exposure, 93% of Americans have a measurable amount of BPA in their urine (7, 8).”
• Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention (2019, background): “6% of persons ≥6 years of age in the US [68].”