Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

By A. Schinkel, J. Jonker. Advanced Drug Delivery Reviews, 2003

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Targeting multidrug resistance in cancer (2006, background): “Transported substrates include cytotoxic drugs, toxins and carcinogens found in food products, as well as endogenous compound”
Modelling of the blood–brain barrier in drug discovery and development (2007, background): “Thus far, the mammalian MRP family consists of nine protein”
ABC multidrug transporters: structure, function and role in chemoresistance. (2008, background): “Several of these proteins are multidrug efflux pumps that not only protect the body from exogenous toxins, but also play an important role in the uptake and distribution of therapeutic drugs [4].”
Drug resistance in brain diseases and the role of drug efflux transporters (2005, background): “All cells express efflux transporters that protect them from endogenous or exogenous toxic substance”
Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions (2006, background): “BMVEC possesses the so-called multidrug resistance (MDR) proteins, a phenotype first described for chemotherapy-resistant cancer cells that overexpressed one of these efflux transporters, P-gp (Schinkel and Jonker 2003).”