Modelling of the blood–brain barrier in drug discovery and development

By R. Cecchelli, V. Bérézowski, S. Lundquist, M. Culot, Mila Renftel, M. Dehouck, L. Fenart. Nature reviews. Drug discovery, 2007

608 citations recorded by the source corpus.

Subfields: Oncology, Pediatrics, Perinatology and Child Health, Pharmacology

View Paper: https://www.semanticscholar.org/paper/335f9156e2aa75e8a1577897d865a8dcff050302

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In Oncology

1. Amanda F. Levy
2. Mao Ye
3. Peter C. Searson
4. Jeffrey D. Rothstein
5. D. Bergles
6. Andrew D. Wong

Citations in the corpus

• A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes. (2009, unknown): “A great number of currently used in vitro BBB model is composed of coculture of brain endothelial cells with astrocytes (Deli et al., 2005; Deli, 2007; Cecchelli et al., 2007).”
• The blood-brain barrier: an engineering perspective (2013, methodology): “As described above, BMECs are surrounded by pericytes that extend processes over the capillary surface, a 50–100 nm thick basement membrane, and astrocyte end-feet that almost completely surround the outside of the capillaries.”