Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

By J. Siliciano, Joleen Kajdas, D. Finzi, T. Quinn, K. Chadwick, J. Margolick, C. Kovacs, S. Gange, R. Siliciano. Nature Medicine, 2003

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Stimulation of HIV-1-specific cytolytic T-lymphocytes facilitates elimination of latent viral reservoir after virus reactivation (2012, neutral): “Because of the stability of the reservoir (Siliciano et al., 2003; Strain et al., 2003), life-long antiretroviral therapy is required, raising concerns about adverse effects over decades of therapy, the evolution of resistance, and the financial burden of treatment.”
Replication-competent non-induced proviruses in the latent reservoir increase barrier to HIV-1 cure (2013, background): “This latent reservoir (LR) has a long half-life, preventing cure by ART alone (Finzi et al., 1997; Siliciano et al., 2003; Strain et al., 2003).”
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production (2013, background): “Estimates of the half-life of the HIV latent reservoir in blood indicate that as long as 70 years might be required for the eradication of the latent reservoir in the presence of fully suppressive antiviral therapy (Siliciano et al., 2003).”
Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes (2007, background): “Even with optimal HAART treatment, replication-competent HIV-1 still exists in resting primary CD4 + T cell”
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation (2009, methodology): “We analyzed our data by using a previously described regression mode”