Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia

By Maria Labandeira-Rey, Florence Couzon, S. Boisset, Eric L. Brown, M. Bes, Y. Benito, E. Barbu, Vanessa Vazquez, M. Höök, J. Etienne and 2 more. Science, 2007

700 citations recorded by the source corpus.

Subfields: Infectious Diseases, Microbiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a3589c7b06c5d30d35f888573a05f1c4426469af

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Citations in the corpus

Staphylococcus aureus Elaborates Leukocidin AB To Mediate Escape from within Human Neutrophils (2013, result): “Studies with conflicting outcomes and conclusions (8, 14, 15) were attributed to the species specificity of PVL, wherein human and rabbit cells are highly susceptible to the toxin and murine cells are highly resistant (16).”
The evolution of Staphylococcus aureus. (2008, background): “Furthermore, it has been shown that PVLpositivity is sufficient to cause necrotizing pneumonia in an acute pneumonia mouse model (Labandeira-Rey et al., 2007).”
Staphylococcus aureus leukocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo (2011, background): “aureus pathogenesis on the other hand have led to conflicting conclusions due in part to the toxin’s species specificity, but PVL is believed to contribute to pneumonia (Voyich et al., 2006; Labandeira-Rey et al., 2007; Diep et al., 2010; Loffler et al., 2010).”
Pathogenesis of methicillin-resistant Staphylococcus aureus infection. (2008, background): “S356 • CID 2008:46 (Suppl 5) • Gordon and Lowy age, weight loss, and increased mortality in a concentrationdependent fashion [94].”
Community-Associated Methicillin-Resistant Staphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic (2010, background): “demonstrated that both the purified PVL protein and an RN6390 derivative with the PVL genes overexpressed on an introduced phage caused necrotizing pneumonia in a mouse model (498).”
Genome Sequence of Staphylococcus aureus Strain Newman and Comparative Analysis of Staphylococcal Genomes: Polymorphism and Evolution of Two Major Pathogenicity Islands (2007, background): “aureus MW2, genes for enterotoxin H (seh) and collagen-binding protein (cna) are located within genome islets (1) and Panton-Valentine leukocidin component genes, whose product is responsible for fatal outcomes in humans such as necrotizing pneumonia (20) in a prophage; however, these virulence gene”
Characterization of a new cytotoxin that contributes to Staphylococcus aureus pathogenesis (2010, background): “The focus of most studies in the staphylococcal toxin field has been on g-haemolysin (Menestrina et al., 2003), PVL (Voyich et al., 2006; Labandeira-Rey et al., 2007; Brown et al., 2009; Accepted 26 November, 2010.”
Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular (2015, background): “In contrast, variable contributions of PVL to virulence have been demonstrated in mouse models of keratitis, pneumonia, bone and muscle infections [5,10–13].”