Staphylococcus aureus Elaborates Leukocidin AB To Mediate Escape from within Human Neutrophils

By Ashley L. DuMont, Pauline Yoong, Bas G. J. Surewaard, M. A. Benson, R. Nijland, J. V. van Strijp, Victor J. Torres. 2013

143 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Infectious Diseases

In Molecular Biology

Citations in the corpus

Staphylococcus aureus toxins (2013, background): “Among the other leukocidins, only LukAB (LukGH) also lyses neutrophils after uptake [26,27].”
The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus (2014, background): “Ex vivo infection models using primary human cells offer an alternate perspective into the perceived virulence potential of LukAB/HG (97, 234).”
Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular (2015, methodology): “THP1 infection assays under non-phagocytosing and phagocytosing conditions were modified from a previous study [25].”
Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection. (2013, background): “Importantly, the recent identification of unique leukotoxin receptors for LukED, LukSF-PV/PVL and LukAB implies that although each toxin can target PMNs, they do so in a non-redundant manner (Alonzo et al., 2013; Dumont et al., 2013a; Spaan et al., 2013a).”
Exploiting dominant‐negative toxins to combat Staphylococcus aureus pathogenesis (2016, unknown): “At this time point, the contribution of LukAB to USA300 secretome-mediated killing of PMN is minimal due to the lack of LukAB in the culture filtrates [43].”
Staphylococcus aureus Impairs the Function of and Kills Human Dendritic Cells via the LukAB Toxin (2019, methodology): “Previously, it was shown that human PMNs induce the expression and production of LukAB (11, 21, 22), which is associated with the dominant role of this toxin in infections using primary human PMNs (11, 20, 23).”
Evolution of hypervirulence by a MRSA clone through acquisition of a transposable element (2014, methodology): “Briefly, 2 × 105 PMNs per well were plated in 96-well tissue culture treated plates in a final volume of 100 μl RPMI (Gibco) supplemented with 10% heat-inactivated fetal bovine serum.”