Physical Activity and Reduced Risk of Cardiovascular Events: Potential Mediating Mechanisms

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Reprint: 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk. (2014, background): “Among the mechanisms proposed to mediate the relationship between physical activity and decreased CVD rates are beneficial effects of exercise on lipid profile and BP (106).”
Aerobic Exercise and Neurocognitive Performance: a Meta-Analytic Review of Randomized Controlled Trials (2010, background): “Alternatively, it is also possible that combined interventions may result in greater improvements in vascular health (100) and basal levels of inflammation (101,102), although these relationships have yet to be investigated.”
Exercise is the real polypill. (2013, background): “, C-reactive protein, fibrinogen) making the largest contribution to PA reduction of CVD, followed by BP, lipids, and body mass index (319).”
Physical Activity and Risk of Cardiovascular Disease—A Meta-Analysis of Prospective Cohort Studies (2012, background): “Third, some of the protective factors reinforced by PA may be responsible for risk reduction in CHD specifically, such as attenuated plaque progression in coronary arteries, enhanced collateralization of coronary arteries, or infarct sparing due to myocardial preconditioning [43-45].”