Learning Induces Long-Term Potentiation in the Hippocampus

By Jonathan R. Whitlock, Arnold J. Heynen, Marshall G. Shuler, Mark F. Bear. Science, 2006

1,933 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/a3355c6f65702d15558ef0eeb82ca7b5fc966a75

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Y. Dudai
2. John T. Wixted
3. A. Citri
4. R. Malenka
5. Lisa Genzel
6. Giulio Tononi
7. Chiara Cirelli
8. Richard G. M. Morris

In Cognitive Neuroscience

1. John T. Wixted
2. Y. Dudai
3. Giulio Tononi
4. Lisa Genzel
5. Chiara Cirelli
6. L. R. Squire
7. R. Malenka
8. Richard G. M. Morris

Citations in the corpus

• Plasticity during stroke recovery: from synapse to behaviour (2009, background): “Mounting evidence supports a fundamental role for Hebbian mechanisms in producing activity-dependent changes in synaptic strength in models of learning and memor”
• Synaptic plasticity, memory and the hippocampus: a neural network approach to causality (2008, result): “Several recent studies have detected LTP-like synaptic changes in the hippocampu”
• Dendritic excitability and synaptic plasticity. (2008, neutral): “such as the hippocampus (538, 828) and neocortex (632,”
• TrkB signalling pathways in LTP and learning (2009, background): “This has made L-LTP induction an attractive candidate for the molecular analogue of long-term memory (LTM”
• EPIGENETIC REGULATION OF BDNF GENE TRANSCRIPTION IN THE CONSOLIDATION OF FEAR MEMORY (2008, background): “, 2006), a leading candidate cellular mechanism for associative memory formation (Bliss and Collingridge, 1993; Whitlock et al., 2006).”
• Glutamate Receptor Ion Channels: Structure, Regulation, and Function (2010, background): “In vivo evidence from transgenic animals suggests that GluA1 phosphorylation is critical for synaptic plasticity (Lee et al., 2000, 2003; Whitlock et al., 2006; Tsui and Malenka, 2006).”
• Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “After briefly reviewing short-lasting forms of synaptic plasticity, we will emphasize current understanding of the cellular mechanisms and possible functions of the class of phenomena commonly termed long-term potentiation (LTP) and long-term depression (LTD).”
• Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration (2014, background): “…2006), association learning (Gruart et al., 2006), contextual memory formation (Hu et al., 2007), fear conditioning (Matsuo et al., 2008; Rumpel et al., 2005), visual perceptual learning (Sale et al., 2011), cue-reward learning (Tye et al., 2008), and avoidance learning (Whitlock et al., 2006).”
• Mechanisms of CaMKII action in long-term potentiation (2012, background): “, and similar changes in synaptic strength occur during learnin”
• Event Timing in Associative Learning: From Biochemical Reaction Dynamics to Behavioural Observations (2012, background): “olfactory learning; whereas few studies exist in other systems, e.g.,”
• Towards a glutamate hypothesis of depression (2011, background): “…is widely accepted that plasticity occurring at glutamate synapses allows the encoding of new information, a hypothesis further validated by the findings that both sensory stimulation and learning processes in vivo induce LTP in the hippocampus (Holtmaat and Svoboda, 2009; Whitlock et al., 2006).”
• Maternal Care and Hippocampal Plasticity: Evidence for Experience-Dependent Structural Plasticity, Altered Synaptic Functioning, and Differential Responsiveness to Glucocorticoids and Stress (2008, background): “Examples of successful prediction can be appreciated from recent studies showing that hippocampal LTP occurs during hippocampal learning (Whitlock et al., 2006) in behaving animals.”