Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β

By Xin Lin, A. O’Mahony, Y. Mu, R. Geleziunas, W. Greene. Molecular and Cellular Biology, 2000

260 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/a2daf0b9ca5b2787e70d256aeb6cd5bfdf8e640f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. S. Ghosh
2. M. Hayden
3. A. West
4. N. Perkins
5. M. Karin
6. Shao-Cong Sun
7. O. Maier
8. Roman Fischer

In Immunology

1. S. Ghosh
2. M. Hayden
3. A. West
4. J. Bluestone
5. N. Perkins
6. Shao-Cong Sun
7. Shizuo Akira
8. M. Karin

In Oncology

1. M. Hayden
2. S. Ghosh
3. J. Bluestone
4. Shao-Cong Sun
5. O. Maier
6. Roman Fischer

Citations in the corpus

• CD28 costimulation: from mechanism to therapy (2016, background): “PDK1 in turn phosphorylates and activates PKCq, a critical downstream effector of CD28, which mediates signaling events leading to the activation of the NF-kB, AP-1, and NF-AT transcription factors (Coudronniere et al., 2000; Dodson et al., 2009; Lin et al., 2000).”
• NF-κB and the immune response (2006, background): “Although there has been some controversy, available data suggest that PKCy is largely essential for activation of NF-kB via T-cell stimulation (Sun et al., 2000; Pfeifhofer et al., 2003) and can mediate the activation of IKK (Lin et al., 2000).”