A Tlr7 translocation accelerates systemic autoimmunity in murine lupus.

By S. Subramanian, Katalin Tus, Quanzhen Li, Andrew Wang, Xiang-Hong Tian, Jinchun Zhou, C. Liang, Guy Bartov, L. McDaniel, Xin J. Zhou and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2006

668 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/a2b21f52150eeff612c832b2cc514d857d53b12e

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In Immunology

Citations in the corpus

Type I interferon in systemic lupus erythematosus and other autoimmune diseases. (2006, background): “Sle1.yaa mice carrying a polymorphic cluster encoding SLAM and CD2 in addition to a duplication in TLR7 (Subramanian et al., 2006).”
Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion (2011, background): “Furthermore, although several mouse studies show that over- representation of Tfh cells is associated with the development of systemic autoimmunity (Linterman et al., 2009; Subramanian et al., 2006; Vinuesa et al., 2005), their association with human autoimmune diseases remains largely unknown.”
Murine Models of Systemic Lupus Erythematosus (2011, background): “It is now known that Yaa is due to a translocation of the telomeric end of the X chromosome to the Y chromosome, resulting in the duplication of at least 16 genes and a ∼2fold expression in many of these genes [54, 55].”
Pattern recognition receptors and inflammation. (2010, background): “In addition to JEV, another flavivirus, hepatitis C virus (HCV), is also recognized by RIG-I, whereas both RIG-I and MDA5 redundantly recognize Dengue virus and West Nile virus (Loo et al., 2008; Sumpter et al., 2005).”
T follicular helper (TFH) cells in normal and dysregulated immune responses. (2008, background): “Moreover, two different murine models of human lupus are characterized by a TFH cell–like transcriptome in their spleens (53, 136).”
Trex1 prevents cell-intrinsic initiation of autoimmunity (2008, positive): “However, the ISD pathway engages a distinct signaling cascade that is IPS-1-independent (Kumar et al., 2006; Sun et al., 2006), possibly through activation of the candidate ISD sensor DAI (Takaoka et al., 2007).”