Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia.

By L. Bullinger, K. Döhner, Eric Bair, S. Fröhling, R. Schlenk, Robert Tibshirani, H. Döhner, Jonathan R. Pollack. New England Journal of Medicine, 2004

1,013 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a27443c3623131f5867a257d6e7cc17cde389308

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Stem cell gene expression programs influence clinical outcome in human leukemia (2011, neutral): “Previously identified prognostic AML gene signature”
Feature Selection via Dependence Maximization (2012, neutral): “, 2001; West, 2003) (9, 10), and two with leukaemia (Bullinger et al., 2004; Valk et al., 2004) (16, 17).”
Densely interconnected transcriptional circuits control cell states in human hematopoiesis (2011, neutral): “Impaired or blocked hematopoietic differentiation is a defining characteristic of leukemia, and the gene expression profiles of leukemias cluster strongly into subgroups that correspond to specific molecular subgroups (Bullinger et al., 2004; Tamayo et al., 2007; Valk et al., 2004).”
Heritable GATA2 Mutations Associated with Familial Myelodysplastic Syndrome and Acute Myeloid Leukemia (2011, background): “Further, chromosomal aberrations at the 3q21 breakpoint cluster encompassing a presumptive GATA2 regulatory region resulted in upregulated GATA2 expression in MDS and AM”
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia (2011, methodology): “In addition, the expression of DNMT3A is low in AML-M4 and AML-M5 compared with other subtypes of acute myeloid leukemi”
Simultaneous Inference in General Parametric Models (2008, neutral): “Bullinger et al. (2004) Again, a sandwich estimator of the covariance matrix S n can be plugged-in but the results stay very much the same in this case.”
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. (2005, background): “The unfavorable-risk category was defined by the presence of -5/del(5q), 7del(7q), t(6;9), t(9;22), 3q26 abnormality or complex karyotype (more than 3 abnormalities).”