Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.
By Pablo Huertas, A. Aguilera. Molecules and Cells, 2003
756 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/a240a7bf458398334a58648705c08f41ab74aace
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In Genetics
In Molecular Biology
- A. Aguilera
- J. Manley
- Tatiana García-Muse
- Morgane Macheret
- Belén Gómez‐González
- J. Haber
- Xialu Li
- T. Halazonetis
Citations in the corpus
- Sources of DNA double-strand breaks and models of recombinational DNA repair. (2014, background): “Apart from hindering replication fork progression (Prado and Aguilera 2005), R-loops, three-strand nucleic acid structures formed by an RNA:DNA hybrid, plus a displaced single-stranded DNA (ssDNA) identical to the RNA molecule, have been linked to mutagenesis, recombination, and chromosome rearrange”
- DNA replication stress as a hallmark of cancer. (2015, background): “Alternatively, RNA:DNA hybrids formed during transcription might impede fork progression (115).”
- R loops: from transcription byproducts to threats to genome stability. (2012, background): “…that mutants of THO/TREX, a conserved protein complex initially identified in yeast as involved in transcription and mRNA export, accumulate cotranscriptional R loops was the first evidence that RNA metabolic functions have a role in preventing R loops (Huertas and Aguilera, 2003) (Figure 2A).”
- Genome instability: a mechanistic view of its causes and consequences (2008, background): “However, R loops are linked to transcription-associated GIN in mutants that are defective in the biogenesis and processing of messenger ribonucleoprotein (mRNP) particles in yeast, chicken and human cell”
- Pre-mRNA processing reaches back to transcription and ahead to translation. (2009, neutral): “Further characterization of specific genes in these affected mutant strains revealed elongation defects that were rescued by overexpressing RNase H or by incorporating ribozymes into the transcribed genes (Huertas and Aguilera, 2003).”
- Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. (2005, background): “( Huertas and Aguilera, 2003).”