Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability.
By Xialu Li, J. Manley. Cell, 2005
773 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/33f85301357aa1e18432b07232294e65d4888897
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In Cardiology and Cardiovascular Medicine
In Molecular Biology
- Chuan He
- Tatiana García-Muse
- A. Aguilera
- T. Cooper
- Zhike Lu
- Qing Dai
- Xiu-Jie Wang
- Belén Gómez‐González
Citations in the corpus
- R loops: from transcription byproducts to threats to genome stability. (2012, background): “In human and chicken DT40 cells, the ASF/SF2 splicing factor prevents R loop formation (Li and Manley, 2005).”
- Functional consequences of developmentally regulated alternative splicing (2011, background): “SR proteins have an established relevance to cell cycle control and oncogenesi”
- The gene encoding the splicing factor SF2/ASF is a proto-oncogene (2007, background): “Knockdown of SF2/ASF can induce genomic instability, including double-stranded DNA breaks and a high rate of mutation”
- Pre-mRNA processing reaches back to transcription and ahead to translation. (2009, neutral): “This chemical treatment modifies single-strand dC residues to dU, which can then be detected by DNA sequence analysis (Li and Manley, 2005).”
- ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility (2012, background): “Hyperphosphorylated ASF/SF2 is involved in pre-mRNA splicing while hypophosphorylated ASF/SF2 bridges the interaction of the TAP-p15 complex andmRNAcargo to facilitatemRNA export (Li and Manley, 2005; Michlewski et al., 2008).”
- Genome instability: a mechanistic view of its causes and consequences (2008, background): “However, R loops are linked to transcription-associated GIN in mutants that are defective in the biogenesis and processing of messenger ribonucleoprotein (mRNP) particles in yeast, chicken and human cell”
- Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination (2011, positive): “Interestingly, previous studies demonstrated that defects in splicing induced by the depletion of SR splicing factor ASF/SF2 correlate with increased Rloop levels, resulting in genome instability (Li and Manley, 2005).”