Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus.

By B. Goodpaster, F. L. Thaete, D. Kelley. American Journal of Clinical Nutrition, 2000

705 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/a2313454baf48ef55ae4464fa24cbfc979bd2c0f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. Ralph DeFronzo
2. Anne B. Newman
3. I. Tabas
4. K. Bornfeldt

In Epidemiology

1. Ralph DeFronzo
2. Anne B. Newman
3. D. Kelley
4. B. Goodpaster
5. K. Bornfeldt
6. I. Tabas

In Physiology

1. Ralph DeFronzo
2. Tamara B. Harris
3. Marjolein Visser
4. Todd M. Manini
5. Anne B. Newman
6. B. Goodpaster
7. M. Nevitt
8. Lawrence J. Mandarino

Citations in the corpus

• Pathogenesis of type 2 diabetes mellitus. (2004, background): “In addition to the FFA that circulate in plasma in increased amounts, type 2 diabetic and obese nondiabetic individuals have increased stores of triglycerides in muscle and liver, and the increased fat content correlates closely with the presence of insulin resistance in these tissues [153–156].”
• Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. (2004, background): “It should be noted that the same scenario would ensue if the FFA were derived from triglycerides stored in muscle (34, 35) or from plasma (21, 28, 29).”
• Longitudinal study of muscle strength, quality, and adipose tissue infiltration. (2009, background): “For instance, we (26) previously observed that, despite accounting for only’8% of total thigh fat, IMF, but not SF, is correlated with insulin resistance and the metabolic syndrome (26–28) and is proportionately greater in those with diabetes mellitus (27).”
• Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study. (2001, background): “These peaks are readily separable (10), and the areas of adipose tissue and muscle in the entire image were determined by the areas under their respective peaks of the histogram.”
• Intermuscular Fat: A Review of the Consequences and Causes (2014, background): “Compared to subcutaneous fat, IMAT is a much smaller fat depot, accounting for as little as 8% of the adipose tissue in the thigh [5].”
• Measurement of skeletal muscle radiation attenuation and basis of its biological variation (2014, background): “Some authors defined low attenuation muscle from 0 to +29 HU (Goodpaster et al. 2000b, Deriaz et al. 2001, Lee et al. 2005), while others included 29 to +30 HU.”