Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria.

By Subra Suresh, Joachim Pius Spatz, J. P. Mills, A. Micoulet, Ming Dao, Chwee Teck Lim, M. Beil, T. Seufferlein. Acta Biomaterialia, 2005

896 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/a1fac75ef412ba675e53f72ba6c2889fc20b90e3

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Citations in the corpus

Particle separation and sorting in microfluidic devices: a review (2014, methodology): “In diagnostics, the separation techniques can be utilized to separate living cells from dead cells, cancer cells from normal cells and malaria-infected cells from healthy cells (Suresh et al. 2005; Alshareef et al. 2011).”
Optical tweezers and their applications (2018, methodology): “pathological conditions [142, 143], and optical tweezers have been used to test several of these including malaria (plasmodium falciparum) [144, 145], diabetic retinopathy [146] and birdshot chorioretinopathy [147].”
In Situ Single Cell Mechanics Characterization of Yeast Cells Using Nanoneedles Inside Environmental SEM (2008, background): “THE ELASTIC modulus of the living cells can be either increased or decreased depending on the structure and molecular alterations induced by the onset and progression of diseases caused by the invasion by foreign organisms such as parasites [1], [2].”
Review on Cell Mechanics: Experimental and Modeling Approaches (2013, methodology): “Lastly, optical tweezers have been used to simultaneously assess the mechanical and electrical properties of cells [206], and to stretch nonadherent cells [177,207].”
Hydrodynamic stretching of single cells for large population mechanical phenotyping (2012, background): “Besides changes in chromatin density and nuclear architecture, cytosolic cytoskeletal components are expected to contribute to cell deformability measurements and response to mechanical stimuli (1).”
Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells (2012, background): “For example, invasive tumor cells mechanically soften and modify their adhesion to extracellular matrix, which enhances their capacity to escape the primary tumor [5,17,18].”
Biomechanics and biophysics of cancer cells. (2007, methodology): “SPC-induced molecular reorganization of the Panc-1 human epithelial pancreatic cancer cells and the consequent changes in mechanical deformability of the cells have been examined as possible pathways that facilitate easier migration and increased metastatic competence of pancreatic tumor cells [71,1”
Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum (2008, methodology): “4B), which compares well with independent modulus measurements, extracted for healthy RBCs from micropipette aspiration and optical tweezers (14, 21, 22).”
Finite Element Simulation of the Micropipette Aspiration of a Living Cell Undergoing Large Viscoelastic Deformation (2005, background): “Two examples of such diseases include cancer and malaria [ 5 ].”
Theoretical and computational hierarchical nanomechanics of protein materials: Deformation and fracture (2008, background): “4), as reflected in development and utilization of Atomic Force Microscope (AFM) [34,35], optical tweezers [10,13,29,36] or nanoindentation [11,12,37,38] to analyze biological materials.”
Particle tracking in living cells: a review of the mean square displacement method and beyond (2013, methodology): “Such techniques include microplate stretchers (Asnacios et al. 2006; Suresh et al. 2005; Thoumine et al. 1999), an optical stretcher (Guck et al. 2005), microfluidics devices (Hou et al. 2009; Qi et al. 2012), micropipette aspiration (Evans et al. 1995; Guo et al. 2012), applied shear flow, or…”
Nanomechanical analysis of cells from cancer patients. (2007, background): “In particular, several studies have shown a reduction in stiffness with increasing metastatic efficiency in human cancer cell lines using several different in vitro biomechanical assays (see, for example, refs&nbs”
A particle-based model for the transport of erythrocytes in capillaries (2009, background): “Several human diseases are caused by pathological changes in the mechanical properties of cells (Suresh et al. 2005; Lee & Lim 2007).”