Biomechanics and biophysics of cancer cells.

By Subra Suresh. Acta Biomaterialia, 2007

1,602 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Biomedical Engineering, Cell Biology

View Paper: https://www.semanticscholar.org/paper/1cc22b63795edae794ce1006bd29beeb88607bf3

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In Atomic and Molecular Physics, and Optics

In Biomedical Engineering

In Cell Biology

Citations in the corpus

Mechanotransduction gone awry (2009, background): “In the past decade, sudden changes in ECM mechanics, ECM remodelling and the resultant disturbance in cytoskeletal tension and mechanotransduction signalling have emerged as important factors that can promote malignant transformation, tumorigenesis and metastasi”
Particle tracking in living cells: a review of the mean square displacement method and beyond (2013, background): “…stretchers (Asnacios et al. 2006; Suresh et al. 2005; Thoumine et al. 1999), an optical stretcher (Guck et al. 2005), microfluidics devices (Hou et al. 2009; Qi et al. 2012), micropipette aspiration (Evans et al. 1995; Guo et al. 2012), applied shear flow, or substrate stretching (Suresh 2007).”
The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells (2009, background): “A growing literature indicates that the biomechanical properties of cells and the surrounding ECM directly influence and are influenced by the progression of neoplastic disease (17, 18).”
Atomic force microscopy as a multifunctional molecular toolbox in nanobiotechnology. (2008, background): “This suggests that AFM-based nanomechanical measurements have a strong potential in biomedicine for the detection of diseases such as cance”
Mechanical compression drives cancer cells toward invasive phenotype (2011, result): “Previous reports have shown that MCF10A cells have a higher apparent elastic modulus than cancer cells (31, 46).”
Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells (2012, background): “3 and Table 2, are consistent with previous reports linking cellular deformability with tumorgenic and metastatic potential [5,7,33].”
Acoustic separation of circulating tumor cells (2015, positive): “As a complementary strategy, antibody-independent methods allow the separation of CTCs based on their physical properties, such as size, deformability, and electrical properties without the need to choose a priori the correct antibodies (7).”
A tense situation: forcing tumour progression (2009, background): “Epithelial cancers are characterized by an altered tissue tensional homeostasis that reflects differences in rheology and increased cell-generated force in the transformed cell”