A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria.

By A. Macpherson, D. Gatto, Elizabeth Sainsbury, G. Harriman, H. Hengartner, R. Zinkernagel. Science, 2000

1,162 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

IgA production without μ or δ chain expression in developing B cells (2001, background): “To determine whether production of IgA in μMT mice was dependent on cognate T cell hel”
Gut microbiome-host interactions in health and disease (2011, background): “The gut microbiota also influence drug metabolism and toxicity [11], dietary calorific bioavailability [12], immune system conditioning and response [13], and post-surgical recovery [14].”
Intestinal permeability – a new target for disease prevention and therapy (2014, background): “B cell activation and proliferation leading to antigen-specific sIgA production occurs in the gut associated lymphoid tissue (GALT) via T cell dependent pathways [41].”
Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases. (2004, background): “[32] Macpherson AJ, Gatto D, Sainsbury E, Harriman GR, Herngartner”