The Current Revolution in Cryo-EM.

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Critical Assessment of Methods of Protein Structure Prediction (CASP) – Round XIII (2019, background): “One significant change in target composition in CASP13 was from the ongoing revolution in high resolution cryo electron microscopy (EM).(2) There are EM targets for a total of six complexes (four heteromeric) and one protein monomer.”
Solving the scalability issue in quantum-based refinement: Q|R#1. (2017, methodology): “Introduction Crystallography is the dominant method for obtaining the atomic structure of a protein; however, it has recently been reported that a cryo-EM revolution is under way (Egelman, 2016; Kühlbrandt, 2014; Callaway, 2015).”