Molecular Signals of Epigenetic States

By R. Bonasio, S. Tu, D. Reinberg. Science, 2010

924 citations recorded by the source corpus.

Epigenetic signals are responsible for the establishment, maintenance, and reversal of metastable transcriptional states that are fundamental for the cell’s ability to “remember” past events, such as changes in the external environment or developmental cues. Complex epigenetic states are orchestrated by several converging and reinforcing signals, including transcription factors, noncoding RNAs, DNA methylation, and histone modifications. Although all of these pathways modulate transcription from chromatin in vivo, the mechanisms by which epigenetic information is transmitted through cell division remain unclear. Because epigenetic states are metastable and change in response to the appropriate signals, a deeper understanding of their molecular framework will allow us to tackle the dysregulation of epigenetics in disease.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a18fbff79418f690335a3a357d198e72b436c390

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Citations in the corpus

Transcriptional Regulation and its Misregulation in Disease (2013, positive): “…chromatin regulators, leading to a present-day consensus model for selective gene control (Adelman and Lis, 2012; Bannister and Kouzarides, 2011; Bonasio et al., 2010; Conaway and Conaway, 2011; Fuda et al., 2009; Ho and Crabtree, 2010; Roeder, 2005; Spitz and Furlong, 2012; Taatjes, 2010; Zhou…”
Molecular mechanisms of long noncoding RNAs (2011, background): “…or as a complementary target for small regulatory RNAs; guidance in trans can occur by lncRNA binding to target DNA as a RNA:DNA heteroduplex, as RNA:DNA:DNA triplex, or RNA recognition of complex surface of specific chromatin features (reviewed by Hung and Chang, 2010; Bonasio et al., 2010).”
Genome regulation by long noncoding RNAs (2012, background): “How does a lncRNA interface with selective regions of the genome? Several hypotheses that have been forwarded, including (i) formation of a RNA: DNA:DNA triplex; (ii) RNA binding to a sequence-specific DNA binding protein; (iii) RNA: DNA hybrid that displaces a single-strand of DNA (so called R-loop”
The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. (2016, background): “Many heterochromatininducing proteins can bind to methylated histones and promote the methylation of adjacent nucleosomes, a property well suited for maintaining self-sustaining gene repression (Bonasio et al. 2010).”
Control of Embryonic Stem Cell State (2011, background): “The molecular mechanisms by which these regulators generally participate in control of gene expression are the subject of other reviews (Bartel, 2009; Bonasio et al., 2010; Fuda et al., 2009; Ho and Crabtree, 2010; Li et al., 2007; Roeder, 2005; Surface et al., 2010; Taatjes, 2010).”
Abscisic Acid and Abiotic Stress Tolerance in Crop Plants (2016, background): “Epigenetic Regulation of ABA Response Epigenetics are the changes in gene function that are not due to changes in DNA nucleotide sequence, but rather due to chemical modification of DNA and its associated proteins (Bonasio et al., 2010).”
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain (2011, neutral): “5hmC has also been hypothesized as a potential intermediate for active DNA demethylation (Bonasio et al., 2010; Feng et al., 2010b; Hajkova et al., 2010; Ito et al., 2010; Wu and Zhang, 2010; Xu et al., 2011).”