A mechanism for impaired fear recognition after amygdala damage

By Ralph Adolphs, F. Gosselin, Tony W. Buchanan, Daniel Tranel, Philippe G. Schyns, Antonio R. Damasio. Nature, 2005

1,318 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/a1163afce9786b37c85ef7df12b399eaf43d94b3

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Citations in the corpus

Neuroscientific Evidence for Simulation and Shared Substrates in Emotion Recognition: Beyond Faces (2009, background): “…SM, provided convergent evidence about the necessity of the amygdala for normal direction of attention to the eyes in emotional face processing (Adolphs et al., 2005): SM and a group of demographically matched control subjects were asked to make two-alternative (happy vs. fear) emotion…”
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans (2005, background): “…activate the amygdala (Whalen et al., 1998), and lesions of the amygdala impair recognition of fearful faces and lead to social disinhibition (Adolphs et al., 2005) Decreased amygdala activation has been linked to genetic hypersociability (MeyerLindenberg et al., 2005) and increased…”
Young children with Autism Spectrum Disorder look differently at positive versus negative emotional faces (2008, background): “, Anderson, Christoff, Panitz, DeRosa, & Gabrieli, 2003; Davis, 2000, but also see Hamann, Ely, Hoffman, & Kilts, 2002) and recent evidence suggests that this structure is directly involved also in directing gaze at the eyes which is crucial for detecting information about negative emotions (Adolphs”
Emotion processing and the amygdala: from a ‘low road’ to ‘many roads’ of evaluating biological significance (2010, neutral): “Indeed, a study in a patient with bilateral amygdala lesions showed that this patient's impaired recognition of facial expressions of fear was due to impaired processing of the eye region of faces, especially of high-spatial-frequency information about the eye”
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. (2008, neutral): “A vast area of research in animal, human lesion, and neuroimaging studies points to the critical role of these brain areas in signaling and modulating fear responses (Adolphs et al., 2005; Amaral, 2003).”
Selective for Whole Faces in the Human Amygdala (2011, background): “Patients with amygdala lesions exhibit facial processing deficits for a variety of different facial expressions, including both fearful and happy [1, 13], and we found that most WF-selective units do not distinguish between fearful and happy, suggesting that the amygdala is concerned with a more gen”
The orbitofrontal cortex and beyond: from affect to decision-making. (2008, background): “The importance of the orbitofrontal cortex in emotion in humans is emphasized by a comparison with the effects of bilateral amygdala damage in humans, which although producing demonstrable deficits in face processing (Adolphs et al., 2005; Spezio et al., 2007), decision-making with linked autonomic ”
Eye-Gaze Direction Modulates Race-Related Amygdala Activity (2008, background): “This is due in part to their failure to exhibit conditioned fear responses (Bechara et al., 1995) as well as their inability to utilize threat-relevant information communicated by the eyes of conspecifi cs (Adolphs et al., 2005).”
The Structure of Emotion (2006, background): “, eye gaze; Adams, Gordon, Baird, Ambady, & Kleck, 2003) modulate whether or not viewing facial caricatures of fear elicits amygdala activation, and even those with amygdala damage can correctly identify those caricatures when attention is directed toward the eyes of the stimulus caricature (Adolphs”
A systems approach to appraisal mechanisms in emotion (2005, neutral): “Recently, Whalen et al. (2004) took advantage of the fact that the eye region of the face is a key region where expression information is extracted (e.g. Adolphs et al., 2005) in order to investigate whether the amygdala is sensitive to fearful eyes presented in isolation.”
Sex differences in scanning faces: Does attention to the eyes explain female superiority in facial expression recognition? (2010, background): “Given that previous studies suggest that reduced attention to the eyes results in poorer facial expression recognition (Adolphs et al., 2005), the present findings may indicate that reduced looking to the eyes by men results in a reduced ability to accurately recognise facial expressions.”
A Developmental Examination of Amygdala Response to Facial Expressions (2008, background): “in a patient with bilateral amygdala damage stems from an inability to use information from the eye region in faces (Adolphs et al., 2005) and other work has found amygdala response to direct eye contact to be an important social signal (Kawashima et al.”
The Biology of Trust: Integrating Evidence From Genetics, Endocrinology, and Functional Brain Imaging (2012, methodology): “…or her beliefs about the individual’s trustworthiness on the basis of stimuli (e.g., appearance, facial expression, or self-control of the trustee; Adolphs et al., 2005; Righetti & Finkenauer, 2011; Todorov, 2008; Winston, Strange, O’Doherty, & Dolan, 2002), which in turn affects the attitude…”
An investigation of basic facial expression recognition in autism spectrum disorders (2008, background): “In line with previous studies of typically developing populations (Adolphs et al., 2005; Emery, 2000; Kohler et al., 2004; Mandal et al., 1992; Smith et al., 2005; Whalen et al., 2004), the control group in Experiment 2 demonstrated the importance of processing the eyes to successfully recognise…”
Controlling low-level image properties: The SHINE toolbox (2010, background): “image sets (e.g., Adolphs et al., 2005; Liu et al., 2002; Losch ky et al., 2007; Mack et al., 2008; Sadr & Sinha, 2001, 2004; Willenbockel et al., 2010; Xu et al., 2005).”