The perils of portliness: causes and consequences of visceral adiposity.

By C. Montague, S. O'Rahilly. Diabetes, 2000

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How researchers see this paper

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Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. (2002, background): “sc abdominal fat remains a matter of debate (72, 74, 75).”
Insulin-sensitive obesity. (2010, result): “Our data confirm previous findings that visceral fat mass is associated with insulin resistance independent of BMI and support the notion that anatomic distribution of adipose tissue is a strong and independent predictor of adverse health outcomes of obesity (25, 28, 44).”
A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes: Role of Free Fatty Acids and Tumor Necrosis Factor α (2005, background): “27 The data of this study suggest that FFAs are an important adipocyte-derived paracrine mediator of inflammation in macrophages because of the following reasons: (1) the release of FFAs from 3T3-L1 is increased when cocultured with RAW264; (2) TNF- increases the release of FFAs from 3T3-L1; and (3)”
Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation in Obese Humans (2007, background): “, mesenteric and omental fat) is associated with insulin resistance and diabetes (1,2).”