A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes: Role of Free Fatty Acids and Tumor Necrosis Factor α

By T. Suganami, Junko Nishida, Yoshihiro Ogawa. Arteriosclerosis, Thrombosis and Vascular Biology, 2005

1,072 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/14eb61d3c812e4ee18c375d778067159413d63d1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Myung‐Sook Choi
2. U. Jung
3. R. Goldberg
4. I. Shimomura

In Physiology

1. Myung‐Sook Choi
2. U. Jung
3. R. Goldberg

Citations in the corpus

• Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications. (2009, background): “Adipose tissue from obese individuals contains activated macrophages that together with adipocytes produce inflammatory adipokines such as MCP-1, MIF, TNF , IL-6, procoagulant substances such as PAI-1, vasculoactive substances such as angiotensinogen and endothelin, and molecules that may contribute”
• Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease (2014, background): “macrophages [29], thereby modulating inflammation of adipose tissue which contributes to obesity-associated metabolic complications.”
• Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. (2008, background): “Large adipocytes release more (saturated) FFAs which can bind to macrophage toll-like receptor-4 (TLR-4) resulting in NF-kB activation ultimately leading to augmented TNF-a production.(46,47) In turn, macrophage-derived TNF-a activates human adipocytes, thereby further inducing lipolysis and enhanci”
• Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. (2013, background): “FFAs eleased from enlarged adipocytes (especially satrated FFAs) can facilitate TNF production in acrophages, which leads to inflammation and ipolysis in adipose tissue [47].”