Gene Regulation by Transcription Factors and MicroRNAs

By O. Hobert. Science, 2008

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Epigenetic choreographers of neurogenesis in the adult mammalian brain (2010, background): “Small non-coding RNAs (microRNAs or miRNAs) have emerged as an important class of gene regulators that use different mechanisms of action but form intricate regulatory interaction networks with chromatin modifiers and transcription factor”
Epigenetic regulation of neurogenesis in the adult mammalian brain (2011, background): “Non-coding RNAs, which are transcribed from non-protein-coding regions, have emerged as an important class of epigenetic regulators that interact with chromatin modifiers and transcription factors to regulate gene expression (Hobert, 2008; Morris, 2009; Iorio et al., 2010).”
Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis (2015, background): “The regulation of multiple genes by miRNA and the demonstration of the differential expression of miRNA in animal cells and tissues has led to the supposition that their mechanism of action is theoretically similar to that of transcription factors [82].”