Depolarization Drives β-Catenin into Neuronal Spines Promoting Changes in Synaptic Structure and Function

By S. Murase, Eric A. Mosser, E. Schuman. 2002

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Critical period plasticity in local cortical circuits (2005, background): “Cell-adhesion molecules can become insensitive to proteases during high levels of activit”
Stability of dendritic spines and synaptic contacts is controlled by αN-catenin (2004, background): “Notably, neural activity induces redistribution of β-catenin into synapse”
β-catenin is critical for dendritic morphogenesis (2003, unknown): “β-catenin is a likely target for such regulation because both its stability and association with cadherins are highly regulated through multiple phosphorylation site”
Cell adhesion molecules: signalling functions at the synapse (2007, background): “Enhancing β-catenin's association with N-cadherin in dendritic spines results in an increased size of postsynaptic PSD-95 clusters and presynaptic vesicle clusters, and the increased frequency of spontaneous excitatory event”
Regulation of cadherin-mediated adhesion in morphogenesis (2005, background): “, the plasticity and regulation of neuronal synapse”
Role of β-Catenin in Synaptic Vesicle Localization and Presynaptic Assembly (2003, unknown): “Indeed, synaptic activity can modulate the distribution of N-cadherin (Bozdagi et al., 2000; Shan et al., 2002) and β-catenin (Murase et al., 2002) and perturbations of classical cadherin function have been shown to affect hippocampal LTP (Manabe et al., 2000; Tanaka et al., 2000; Tang et al.,…”