M1 and M2 Macrophages: Oracles of Health and Disease.

By C. Mills. Critical Reviews in Immunology, 2012

989 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Immunology

View Paper: https://www.semanticscholar.org/paper/a023453cc5c79814e26bcc915641821276cf1451

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. R. Noy
2. A. Choo
3. P. Murray
4. Bin Zhang
5. S. Lim
6. J. Pollard
7. Yijun Yin
8. P. Italiani

In Immunology

1. A. Mantovani
2. A. Sica
3. S. Gordon
4. TA Wynn
5. P. Murray
6. F. Martínez
7. Subhra K. Biswas
8. J. Pollard

Citations in the corpus

• The role of macrophages in the resolution of inflammation. (2019, background): “As initial analyses included only a handful of nonoverlapping markers, a conceptual framework evolved that limited macrophages to an “M1” or “M2” phenotype in an in vivo context, analogous to the Th1/Th2 concept that was dominating T cell biology at that time (40, 41).”
• Macrophage Polarization. (2017, background): “A second misconception concerns the notion that macrophage functions are limited and make “stop” [nitric oxide (NO)] or “go” signals (ornithine), or to paraphrase the original idea, “kill or repair” (31).”
• Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy (2017, background): “Macrophages have been described as responding to this micromilieu with either a pro-inflammatory or an anti-inflammatory phenotype (also referred to as “fight” versus “fix” macrophages, respectively) [2].”
• Tumor-associated macrophages: from mechanisms to therapy (2014, background): “The original in vitro characterizations were extended to in vivo models by Mills and coworkers who called these states M1 (activated) and M2 (alternatively activated) (Mills, 2012).”
• Macrophage activation and polarization: nomenclature and experimental guidelines (2014, positive): “Mills and colleagues went further and proposed that the M1-M2 dichotomy was an intrinsic property of macrophages associated with transitions from inflammation to healing, would occur in the absence of an adaptive immune response, and arose early in evolution (Mills, 2012).”
• Microglial M1/M2 polarization and metabolic states (2016, background): “…activation state is induced by para- 651British Journal of Pharmacology (2016) 173 –649 665 sitic products or associated signals (IL-4 and IL-13) with a longer-term function for resolution and repair (Rutschman et al., 2001; Gordon, 2003; Lawrence and Natoli, 2011; Mills, 2012; Wynn et al., 2013).”
• From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “The description of macrophages polarization is leading immunologists to take a step back and revise their concept on how the immune system works (14, 145).”
• Mesenchymal Stem Cells Secrete Immunologically Active Exosomes (2014, positive): “This profile is reminiscent of M2 macrophages that are known to promote tissue repair and limit injury [44,45].”