‘Intercellular communication: diverse structures for exchange of genetic information’

By M. Mittelbrunn, F. Sánchez‐Madrid. Nature reviews. Molecular cell biology, 2012

640 citations recorded by the source corpus.

An emerging concept is that cellular communication in mammals can be mediated by the exchange of genetic information, mainly in the form of microRNAs. This can occur when extracellular vesicles, such as exosomes, secreted by a donor cell are taken up by an acceptor cell. Transfer of genetic material can also occur through intimate membrane contacts between donor and acceptor cells. Specialized cell–cell contacts, such as synapses, have the potential to combine these modes of genetic transfer.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a01f7d2b0413dc4df924546ae3e8c2f4e801518a

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Citations in the corpus

Biological properties of extracellular vesicles and their physiological functions (2015, background): “Although EVs can be transferred between cells at a distance, the lytic synapse between CD8 cytotoxic T cells and infected target cells or tumour cells (481), aswell as the immune synapse between T cells and antigen-presenting cells (201), provides a specialized platform for the efficient transfer of”
SORTING IT OUT: REGULATION OF EXOSOME LOADING (2014, background): “Therefore, EVs act as mediators of cell-cell communication in many different contexts and pathologies [8].”
Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. (2014, background): “those shed from theplasmamembrane (termed ectosomes, microvesicles or microparticles ), exosomes released from late endosomes (MVB), and apoptotic vesicles, and apoptotic vesicles also called apoptotic bodies [38].”
Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles (2014, positive): “In particular, the knowledge that EVs can shuttle functional nucleic acids between cells (mRNA, miRNA or other RNA species) has fundamentally changed the thinking about gene regulation, as the EVs can regulate the recipient cell at a post-transcriptional level (1 (cid:2) 3).”