When are randomised trials unnecessary? Picking signal from noise

By P. Glasziou, I. Chalmers, M. Rawlins, P. McCulloch. British medical journal, 2007

596 citations recorded by the source corpus.

Subfields: Economics and Econometrics, Statistics and Probability

View Paper: https://www.semanticscholar.org/paper/a016dc157f1a10c6d846830d2e0df1aa7ce019d9

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Citations in the corpus

Interpretation of the evidence for the efficacy and safety of statin therapy. (2016, background): “insulin for diabetic ketoacidosis; penicillin for lobar pneumonia; ganciclovir for cytomegalovirus retinitis).(2,82) However, due to the potential biases that”
Do à la carte menus serve infertility patients? The ethics and regulation of in vitro fertility add-ons. (2019, background): “Except in cases where treatment effects are very large and stable (30-32), it is not known whether a 164 treatment is beneficial or disadvantageous until it has been robustly evaluated, although this point 165”
Developing and evaluating complex interventions: the new Medical Research Council guidance (2008, unknown): “It is important designs preferable (Black, 1996; Glasziou et al., 2007), but”
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. (2011, background): “across agents within the same class) (66), all further the au-”
What is “quality of evidence” and why is it important to clinicians? (2008, background): “Although well done observational studies generally yield low quality evidence, in unusual circumstances they may produce moderate or even high quality evidence (see box).”
GRADE guidelines: 9. Rating up the quality of evidence. (2011, background): “Furthermore, when considering rating up the quality of evidence for magnitude of effect, factors relating to the magnitude include rapidity of treatment response, and the previous underlying trajectory of the condition [6].”
Generating translatable evidence to improve patient care: the contribution of human factors (2020, unknown): “This is the case when the treatment (the signal) indicates an enormous improvement as compared to the natural course of the disease (the noise) (Glasziou et al., 2007) : for example when Lesley Brown conceived after IVF and gave birth to Louise, this proved the treatment to be effective, as Mrs. Bro”