The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells

By R. Steinman, S. Turley, I. Mellman, K. Inaba. Journal of Experimental Medicine, 2000

1,333 citations recorded by the source corpus.

What makes a protein immunogenic, particularly for strong T cell–mediated immunity? To a first approximation, this determination seems to be made by dendritic cells (DCs). Immature DCs, as in skin ([1][1])([2][2])([3][3])([4][4]), lung ([5][5]), blood ([6][6])([7][7]), and spleen ([7][7])([8][8

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/9fddd375cbfc31115e4b07edb231634f28d707e8

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Citations in the corpus

β-Cell death during progression to diabetes (2001, background): “The significance of such a wave of β-cell death in the context of initiation of autoimmunity is that the engulfment of apoptotic and necrotic cells can be a potent activation signal for APCs, in particular DC”
Corpse clearance defines the meaning of cell death (2000, background): “Dendritic cells are specialized for the presentation of ingested antigen to lymphocytes but do so most efficiently if they subsequently receive a maturation or 'danger' signal such as an exposure to microorganism”
Repetitive Injections of Dendritic Cells Matured with Tumor Necrosis Factor α Induce Antigen-specific Protection of Mice from Autoimmunity (2002, background): “As both types of veiled cells and skinderived DCs are detectable under healthy steady-state conditions, they might actively induce tolerance to peripheral tissue antigens in the draining lymph nodes and spleen (33, 34).”
Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells (2001, positive): “, phagocytosed apoptotic cells) might elicit tolerance to naive peripheral T cells in vivo (10, 11).”
Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus (2011, background): “SLE NETs are potent activators of pDCs Apoptosis is normally a tolerogenic form of cell death, because it does not lead to activation and/or maturation of DCs (27).”
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood (2003, background): “Dendritic cells (DCs; reference 13) are being recognized as critical in the maintenance of peripheral tolerance (14).”
Calreticulin exposure dictates the immunogenicity of cancer cell death (2007, background): “This difference was thought to result from the intrinsic capacity of cells dying a nonapoptotic cell death to reduce an immune response—for example, by stimulating local inflammatory responses ('danger signals'), triggering the maturation of dendritic cells (DCs) or bot”
Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo (2000, background): “Lymphoid DCs have been speculated to mediate peripheral tolerance, whereas myeloid DCs have been suggested to be essential for T cell stimulation (49, 63).”
Apoptosis: controlled demolition at the cellular level (2008, background): “However, antigens from ingested apoptotic cells can be presented on the surface of major histocompatibility complex (MHC) molecules of dendritic cells, particularly when combined with a signal that both indicates danger (such as the presence of microorganism-derived peptides) and elicits T-cell resp”