β-Cell death during progression to diabetes

By D. Mathis, L. Vence, C. Benoist. Nature, 2001

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Roles of CHOP/GADD153 in endoplasmic reticulum stress (2004, background): “Excessive loss of β -cells is known to be a cause of diabetes, and apoptosis is the main mode of pancreatic β -cell death in the development of diabetes”
Type 1 diabetes (2013, neutral): “[ 15 ] ).”
The role for endoplasmic reticulum stress in diabetes mellitus. (2008, background): “by and/or expressed on the surface of the immune cells invading the islets, which trigger secondary pathways of cell death in the target -cells (2, 3, 6).”
How dying cells alert the immune system to danger (2008, background): “In the case of autoimmunity, developmentally programmed death of pancreatic β-islet cells precedes the initiation of autoimmune diabetes in non-obese diabetic (NOD) mice”
Type 1 diabetes: etiology, immunology, and therapeutic strategies. (2011, background): “Anti-IL-1 therapies can reduce diabetes incidence in animal prevention models (41, 268, 279).”