Impaired Proteasome Function in Alzheimer's Disease

By J. Keller, Keith B. Hanni, W. Markesbery. Journal of Neurochemistry, 2000

827 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/9f896328d70e99c2280ae57a44108ef1da028275

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. A. Cuervo
2. Ralph A. Nixon

In Molecular Biology

1. A. Cuervo
2. Ralph A. Nixon

In Physiology

1. Ralph A. Nixon
2. A. Cuervo
3. N. Mizushima

Citations in the corpus

• Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation (2004, background): “with Alzheimer’s disease possess decreased proteasome activity (28).”
• Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study (2005, background): “A decline in proteasome-mediated turnover of proteins during aging and AD (13, 14) is one factor that increases reliance on the lysosomal system, the principal alternative to the proteasome for intracellular turnover.”