The systemic inflammatory response syndrome in acute liver failure

By N. Rolando, J. Wade, M. Dávalos, J. Wendon, J. Philpott‐Howard, Roger Williams. Hepatology, 2000

718 citations recorded by the source corpus.

Subfields: Critical Care and Intensive Care Medicine, Hepatology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/9e5d54a463bed75a70fae722260d7bae8f0d6da3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Critical Care and Intensive Care Medicine

1. P. Ginés
2. Rajeshwar P. Mookerjee

In Hepatology

1. P. Ginés
2. Rajeshwar P. Mookerjee
3. G. Garcia‐Tsao
4. P. Kamath

Citations in the corpus

• Acute-on chronic liver failure. (2012, background): “where the presence of SIRS was associated with more severe encephalopathy, associated infection, renal failure, and poor outcome [57–59].”
• Pathophysiology of polytrauma. (2005, background): “The gastrointestinal tract often represents the source for the development of secondary multiple organ failure after trauma, whereas the liver represents the engine, with an acute phase and cytokine response, and decreased function of hepatocytes (increase of serum bilirubin concentration).(130,157,”
• Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL) (2009, background): “Recent studies suggest that the transition from a stable cirrhotic condition to the burst of an acute decompensation leading to liver failure is based on an acute systemic inflammatory response, mainly mediated by cytokines [54].”
• Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014 (2009, neutral): “pointed out that elevated systemic levels are not representative of their role in the pathophysiology of liver failure [52– 54].”
• Hepatic encephalopathy. (2009, background): “Infection/ inflammation have been shown to be associated with development and progression of HE in acute liver failure.(61,62) Approximately 25% of patients with acute liver failure have hyponatremia, which is more prominent in those with severe encephalopathy.”